Vincenzo Barnaba

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Vincenzo Barnaba (Vincenzo Barnaba) carried out his scientific research mainly at the Dipartimento of Internal Medicine of Roma "La Sapienza" – Medicine Faculty. Vincenzo Barnaba has been active as an immunologist for 25 years. The group lead by Vincenzo Barnaba has a long-standing interest in the pathogenesis of immune-mediated diseases, including autoimmune and viral (hepatitis viruses, HIV) diseases. In particular, the Vincenzo Barnaba group’s research aims at establishing the role of HBV and HCV in inducing chronic infection and the role of viruses in inducing autoimmunity, such as the ability of HIV to unveil cryptic self-epitopes.

EDUCATION
Graduate in Medicine and Surgery at the University of Rome, "La Sapienza", 7/12/1973 cum laude
MEMBERSHIPS AND HONOURS
  • Member of the Italian Society of Biochemistry and Molecular Biology(SIB)
  • Member of the Italian Society of Biophysics and Molecular Biology (SIBBM)
  • Honorary Member of the American Society for Biochemistry and Molecular Biology, USA
  • Fellow of the American Biophysical Society, USA
  • Member of EMBO, and of the SAC of EMBL (European Molecular Biology Laboratory)
  • Member of the Accademia Nazionale dei Lincei
  • Premio Nazionale del Presidente della Repubblica (1985)
  • FEBS Lecturer (1989)
  • Member of the Accademia Europea (1996)
  • Officier de l’Ordre National du Mérite du Président de la République Française (2002)
  • Foreign Honorary Member of the American Academy of Arts and Sciences (2006).
EXPERIENCE AND TEACHING
  • Researcher from 16/9/1976 to 23/2/1986
  • Associate Professor of Internal Medicine in the Department of Medicine and Surgery, "La Sapienza", Rome, from 16/7/1985 to November 1990
  • Full Professor of Internal Medicine from November 1990 in the Department of Internal Medicine, University of Rome "La Sapienza”.
  • Head of Laboratory of Cellular and Molecular Immunology in Fondazione Andrea Cesalpino - University of Rome "La Sapienza At the moment his teching duties are:
    • I Medicine faculty
      SAPIENZA, Internal Medicine
    • Biotechnology course
      SAPIENZA, Immunology and Immunopathology
    Vincenzo Barnaba also teaches in several medical specialization courses: Internal Medicine, Immunology, Pharmacy… In addition Vincenzo Barnaba teaches in different PhD programs in Rome, Milan, Paris, Zurig, Munich…
SCIENTIFIC ACTIVITY

Vincenzo Barnaba (Vincenzo Barnaba) carried out his scientific research mainly at the Dipartimento of Internal Medicine of Roma "La Sapienza" – Medicine Faculty. Vincenzo Barnaba has been active as an immunologist for 25 years. The group lead by Vincenzo Barnaba has a long-standing interest in the pathogenesis of immune-mediated diseases, including autoimmune and viral (hepatitis viruses, HIV) diseases. In particular, the Vincenzo Barnaba group’s research aims at establishing the role of HBV and HCV in inducing chronic infection and the role of viruses in inducing autoimmunity, such as the ability of HIV to unveil cryptic self-epitopes.
Otherr Vincenzo Barnaba research fields are the following:

  1. Dynamics of CD8 T cell responses against HCV, HBV, HIV…;
  2. Mechanisms of cross-presentation of exogenous (pathogen- or tumor-associated) antigens to CD8 T cells by dendritic cells;
  3. Mechanisms influencing the differentiation of memory or effector T cells during immunopathology (chronic viral infections, tumors);
  4. Mechanisms controlling unwanted T cell responses (i.e., by regulatory T cells);
  5. proteomic analysis (via 2DE and MALDI-TOF) of apoptotic cells addressed for identifying novel self-antigens recognized by autoreactive T or B cells;
  6. Proteomic analysis (via 2DE and MALDI-TOF) of tumor cells addressed for identifying novel tumor-associated antigens recognized by tumor-specific T cells;
  7. Role of microRNA in the differentiation of memory or effector T cells;
  8. Studies on the role of viruses in autoimmunity. In particular, the role of viruses unveiling cryptic self-epitopes.

 

Vincenzo Barnaba is author or coauthor of about 80 papers on peer reviewed journals, presented about 30 invited as invited speaker at international congresses, conferences and international summer courses.
He spent several research periods in La Jolla Institute of Immunology and Allergy (San Diego, CA) (Dr. Schoenberger), Institute for Research in BioMedicine, Bellinzona (CH) (Dr. A. Lanzavecchia).
Since 1980 he is coordinating scientifically and technically the Cellular and Molecular Immunology Unit of Dipartment of Internal Medicine, SAPIENZA University in Rome, supervising PhD and undergraduate students. He handles personal scientific collaborations with the several research groups around the world, such as Pasteur Institute, Paris (F) (Dr M. Albert), Institute for Research in BioMedicine, Bellinzona (CH) (Dr. A. Lanzavecchia), King’s College in London (Prof. R. Lechler), Institut National de la Santé et de la Recherche Médicale (Inserm), Unité 892, Centre de Recherche en Cancérologie Nantes-Angers, Angers, (F) (Prof. P. Jeannin).

He organised several international congresses and meetings. The last are: Congress “Immunology Today" Kunkel Society Rockfeller Univerity, NY 2007; Symposium How advanced immunology can contribute to new vaccine generations Stransburg 2009; Istituto Pasteur Cenci B. conference on Liver development and disease, Rome, 2009; Gordon conference on II meeting on antigen cross-presentation, Il Ciocco, I, 2009. He is organizing the International Congress of Immunology that will be held in Rome in 2013

He has been or is editorial board member or referee for the following scientific journals:

  • Human Immunology (Editorial Board Member)
  • Hepatology (ex Editorial Board Member)
  • Journal of Hepatology (ex Associated Editor)
  • Viral Immunology (Editorial Board Member)
  • J. Cin. Invest. (referee)
  • Eur. J. Immunol. (referee)
  • J. Immunol. (referee)
  • Nature Med. (referee)
  • Nature Immunology (referee)
  • Immunoloy Letter (referee)