Lorenzo Leoncini "Il linfoma di Burkitt: epidemiologia e patogenesi" - 12 aprile 2018 ore 17.00

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Lorenzo Leoncini, Ordinario di Anatomia Patologica, Università di Siena

"Il linfoma di Burkitt: epidemiologia e patogenesi"

Burkitt lymphoma is reported by the World Health Organization as a highly aggressive B-cell lymphoma. Three clinical variants of Burkitt lymphoma are recognized (endemic, sporadic, immunodeficiency-associated) which differ in geographic distribution, clinical presentation, and association with infectious agents and cell biology. The tumor is composed by monomorphic medium-sized B-cells with basophilic cytoplasm, numerous mitotic figures and an extremely high proliferation rate (Ki-67-index >95%). A «starry sky» pattern is usually present, due to numerous benign macrophages that have ingested apoptotic tumor cells. Tumour cells express membrane IgM with light chain restriction and B-cell-associated antigens CD19, CD20, CD22 and CD79a. Chromosomal translocation involving /MYC/ is the most frequent genetic feature; however, some cases lack /MYC/ translocation. No singleparameter (such asmorphology, genetic analysis or immunophenotyping) can be used as the gold standard for the diagnosis of BL, but a combination of several diagnostic techniques is necessary.